LCB 03-0110

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

LCB 03-0110 是 Discoidin 结构域受体 (DDR) 家族和 c-Src 酪氨酸激酶家族以及 Btk 和 Syk 的有效 ATP 竞争性抑制剂。

LCB 03-0110 is a potent, ATP-competitive inhibitor of Discoidin domain receptor (DDR) family and c-Src tyrosine kinase family, as well as Btk and Syk; potently inhibits the activated tyrosine kinase activity of DDR2 (IC50=6 nM), and nonactivated form of DDR2 (IC50=145 nM); suppresses collagen-induced autophosphorylation of DDR1 and DDR2 with IC50 of 164 and 171 nM in cell-based assays; inhibits all eight Src family kinases with IC50 of 2-20 nM; suppresses the proliferation and migration of primary dermal fibroblasts induced by TGF β1 and type I collagen (IC50=194 nM), inhibits cell migration and nitric oxide, iNOS, COX2, and TNF-α synthesis in LPS-activated J774A.1 macrophage cells; suppresses hypertrophic scar formation in wound healing models.

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LCB03-0110

Tyrosine Kinase

DDR

DDR

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1228102-01-9

417.527

C24H23N3O2S

>98% (HPLC)

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OC1=CC=CC(NC2=C3C(C=C(C4=CC=CC(CN5CCOCC5)=C4)S3)=NC=C2)=C1

3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol

(-20℃)

With Ice Pack

≥ 2 years